Roche said in a statementExternal link on Monday that the studies known as Graduate 1 and 2 did not reach the main goal of showing that the drug gantenerumab can preserve abilities such as memory, solving problems, orientation and personal care in patients suffering from early stages of Alzheimer’s disease.
“The studies did not meet their primary endpoint of slowing clinical decline. Gantenerumab was well tolerated, including the subcutaneous administration,” it said.
The Swiss company conducted two equally designed studies with about 1,000 participants each, who were examined and queried by physicians over more than two years. Within each study, volunteers were randomly assigned to receive either the injectable antibody drug gantenerumab or a placebo.
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Alzheimer cases will more than double by 2050
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Swiss organisations have called for better framework conditions for the prevention, research and treatment of Alzheimer’s and other forms of dementia.
Gantenerumab was designed to bind to aggregated forms of beta-amyloid and remove brain amyloid plaques, which are believed to play a crucial role in the slowly progressing dementia disease.
Most of the 55 million people suffering from dementia worldwide are likely to be affected by Alzheimer’s, according to the World Health Organization (WHO). In 2030, dementia is expected to affect 78 million.
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Brain fingerprints evolve and could help us tackle Alzheimer
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Everyone has a unique brainprint but – unlike finger prints – it can change over time, according to a neuroscientist at the Swiss Federal Institute of Technology in Lausanne (EPFL).
Swiss climate activists block vehicles near Gotthard tunnel
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Around ten climate activists briefly blocked the A2 motorway near the northern entrance of the Gotthard tunnel on Thursday.
Watches belonging to Michael Schumacher up for auction
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Schumacher's family is auctioning off eight rare watches from his collection in Geneva. The Christie's auction will take place on Monday.
Joya Marleen and Baschi named best solo acts at Swiss Music Awards
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St. Gallen singer Joya Marleen and Baschi from Basel were named artists of the year at the Swiss Music Awards 2024 on Wednesday night.
Swiss authorities announce cost-cutting in asylum sector
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The government notably wants to improve integration into the labour force, particularly for people with protection status S.
Various leaders confirm participation at Ukraine peace conference
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The presidents of Poland, Finland, and Latvia and the prime ministers of Spain and Belgium will be at the Swiss-hosted talks in mid-June.
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In the winter season up to April 2024, railway and cable car operators ferried 3% more visitors compared to the previous winter, and 5% more than the five-year average.
Rhine flooding: Swiss to invest CHF1 billion with Austria
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As part of an international agreement with Austria, the Swiss government wants to pump CHF1 billion ($1.1 billion) into flood protection measures along the Rhine over the next three decades.
Swiss government proposes CHF10 million UNRWA donation
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After months of debate, Switzerland plans to give CHF10 million ($11 million) to the UN agency this year, rather than the CHF20 million initially foreseen.
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The end of affordable medicine
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Pharma companies are close to a cure for cancer, but will the hefty price tags make treatments unaffordable for most of the world?
Brain fingerprints evolve and could help us tackle Alzheimer
This content was published on
Everyone has a unique brainprint but - unlike finger prints - it can change over time, according to a neuroscientist at the Swiss Federal Institute of Technology in Lausanne (EPFL).
This content was published on
Swiss organisations have called for better framework conditions for the prevention, research and treatment of Alzheimer’s and other forms of dementia.
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If you want to start a conversation about a topic raised in this article or want to report factual errors, email us at english@swissinfo.ch.